Improving Treatment & Care
For more than four decades, MHIF has focused on innovative clinical studies that change how heart failure is detected, treated, and managed in real-world patients – contributing to advancing care around the world. Our team has research underway investigating everything from advanced imaging and heart rhythm therapies to transplant and mechanical circulatory support, building evidence that directly shapes guidelines and bedside care.
About Heart Failure
Heart failure is a progressive condition that occurs when the heart muscle becomes weakened or stiff and cannot pump enough blood to meet the body’s needs, leading to symptoms such as shortness of breath, fatigue and swelling. It affects an estimated 64 million people worldwide, representing about 1–3% of the global population—a number that continues to rise as populations age and more people survive heart attacks.
As a major final pathway of cardiovascular disease, heart failure contributes significantly to the nearly one in three global deaths caused by cardiovascular conditions, which accounted for roughly 19 million deaths in 2023 alone. It is also a leading cause of hospitalization among older adults and a major driver of emergency visits and readmissions, resulting in billions of dollars in direct medical expenses each year, along with substantial indirect costs from lost productivity and caregiving.
Advancing Heart Failure Care Through Research
Ventricular Assist Devices
While heart transplants have always been viewed as the superior option, the latest research in ventricular assist devices (VADs) has shown that survival outcomes are equivalent to outcomes with heart transplants. Research in VADs has optimized when and how to use the technologies as a bridge or destination therapy, giving years of additional life or until the day a heart transplant becomes available.
Extracorporeal Membrane Oxygenation
MHIF research is advancing care and optimizing outcomes for patients supported by Extracorporeal Membrane Oxygenation (ECMO), a life-sustaining therapy that acts as an artificial heart and lungs giving the patient’s organs a chance to rest.
Pacemaker Devices
MHIF is currently enrolling patients to research technology that helps the pumping efficiency of the heart and improve symptoms by use of a pacemaker-like device. This work promises to improve quality of life.
7 Active Heart Failure & Transplant Studies
Hear From Our Patients
Having been fairly healthy throughout his life, Kevin and his family faced increasing hardships after he experienced not one, but three heart attacks by age 57. After his fourth heart attack, Kevin came to Abbott Northwestern Hospital where he met Dr. Kasia Hryniewicz and learned just how damaged his heart had become.
—Kevin Manion, Heart Transplant
Meet Our Team
Stay Connected
Keep up to date on MHIF news, events and the latest information on heart disease treatment and prevention.